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Metronidazole Gel is an antimicrobial medical product which is successfully used in dermatology and venerology. This drug provides a bactericidal and bacteriostatic action. Depending on the concentration of the active component Metronidazole in the gel this drug shows the most optimal action as to different bacteria and causative agents of the infectious diseases.

Metronidazole Gel also has an antioxidant activity. It is established that it significantly reduces the production of neutrophils of the active oxygen and hydrogen which are the potential oxidants which are able to cause the affection of the tissues in the area of the inflammation. In the course of the drug use it was indicated that it provides the strongest antiprotozoal action. The mechanism of the action consists in the biochemical recovery of 5-nitro group – molecules which are spread in our cells. 5-nitro group interaction with DNA cells of the morbific microorganisms blocking their access to protein. Breaking the protein metabolisms Metronidazole stops the growth and development of bacteria and gradually leads to their death.

This drug is effective as to wide range of the causative agents:    Trichomonas vaginalis, Gardnerella vaginalis, Lambliaspp, Bacteroides vulgatus, Peptococcusspp, and many other aerobic microorganisms, and therefore this drug is often prescribed with peroral antibiotics in order to increase the efficiency of the treatment.

Direction for the use:

  • Urogenital trichomoniasis
  • Gardnerellosis
  • Bacterial vaginosis of the different etiology
  • Never-healing wounds
  • Trophic ulcers

In some cases the gel may be used for the treatment of acne rosacea and acne vulgaris.

Common Use

  • The drug is meant for the external and local use.
  • Metronidazole gel is applied to the clean affected areas of the skin or mucous with thin layer, 2 times a day, in the morning and evening.
  • Maybe, the attending doctor will prescribe another dosage regimen and in this case it is necessary to follow the doctor’s recommendations.
  • Applying the gel it is carefully rubbed by the finger-pads or palm to the affected area
  • The manifested therapeutic effect appears in 2-3 weeks of the treatment.
  • The length of the treatment depends on the efficiency of therapy. The course of the treatment may be from 1 to 4 months.
  • After the end of the course of the treatment it is necessary to have laboratory analyses and make sure of the full healing. If some microorganisms are left, it is necessary to consult a doctor, and if needed, to have another course of the treatment.


  • Using Metronidazole Gel within a long period of time on big parts of the skin the absorption of Metronidazole and development of the system side effects are possible, and therefore it is not recommended patients with dysfunctions of the blood formation to use this drug.
  • The active component of the drug penetrate well to the breast milk, and therefore women are contraindicated the use of the medicine during the lactation or terminate the breast feeding for a while.
  • Metronidazole Gel is contraindicated: in the first term of the pregnancy, increased sensitivity to Metronidazole, or other component in the content of the medicine.
  • During 2 and 3 term of the pregnancy this drug may be used only in case of the emergency but only under the supervision of the qualified medical professional.

Possible Side effects

Metronidazole Gel may cause local reactions: hyperemia, dryness of the skin, feeling of the burning, and irritation of the skin. Using the gel in the area around the eyes lacrimation is possible. These side reactions do not require the medical intervention and pass.

In most cases, following all recommendations to the use this drug does not cause the side effects and are well tolerated.


International name - metronidazole

Metronidazole Gel 20g 5%

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Metrogyl DG 20g dental gel (+ Chlorhexidine Gluconate (0.25 % w/w/1 g.) Metronidazole (1 % w/w)

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