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Tretinoin (Retin-A) is a unique by its action drug for the treatment of acne and some skin diseases. This drug has a unique property to quicken the maturing of the cells of the skin which are a part of the hair bulbs. If these cells are too much, they may block the outlet of the bulbs and outflow of the gland discharge. The malfunction of the outflow of the discharge of sebaceous gland leads to its infection and inflammatory and this leads to the appearance of pustules. If the treatment is absent, pustules become acne in a short period of time and the treatment becomes more complicated because the obstruction of these glands appears and the inflammatory processes are started in other places.

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Tretinoin (Retin-A) provides a fast action due to which it favors the maturing of the skin cells, increases the distance between them and does not give them to clog the outflow of the discharges of the sebaceous gland. Using the drug during the first symptoms of acne when there are open acne on the skin Tretinoin (Retin-A) blocks the inflammatory processes and the process of the acne development does not happen. If the drug is used during the manifested symptoms of acne when there are many closed acne on the skin, this remedy helps to open them and affects them like in the first case.

Nowadays Tretinoin (Retin-A) is one of few drugs which has been approved for the external use during acne. But it is a unique because only this drug has such a fast and effective action. The identical remedies are inferior to this drug in its efficiency. 

Direction for the use:

  • acne vulgaris (especially during formation of comedones, papule, pustules)
  • confluent acne
  • Favre-Racouchot disease

Tretinoin (Retin-A) may be used not only for the treatment of acne but also during different damages of the skin: warts, skin tuberosity, and crinkle of the face. In this case, this drug should be used as an additional remedy together with cosmetic procedures. But the practice showed that the efficiency of the treatment of these skin disorders is increased by several times.

Common Use

  • it is necessary to use Tretinoin (Retin-A) by very thin layer to the affected skins
  • for light and mild forms of acne the cream is applied once per day before going to bed
  • for severe forms of acne when it is necessary to quickly neutralize the development of the disease and clean the skin the cream may be used 2 times per day (in the morning and evening)
  • Tretinoin (Retin-A) should not be rubbed into. It is necessary to wash off the cream from the place of the application in 6 hours and wipe it dry.
  • The length of the therapy is indicated individually. In case of acne of the mild severity the treatment may last 2-3 months; for severer forms the treatment may last up to 5-6 months.
  • It is not recommended to apply the cream more often than it is recommended in the instructions or indicated by your doctor. In case of the overdose by Tretinoin (Retin-A) the patient may experience the increase of the disease symptoms and side effects can appear.


  • During the external use it is necessary to avoid the area of eyes, mouth, and mucous membranes.
  • It is recommended to avoid staying on the sun in the period of the treatment because the ultraviolet effect to the refreshed skin may be unpleasant and dangerous.
  • Tretinoin (Retin-A) is contraindicated in case of solar burns, eczema, psoriasis, seborrheic dermatitis, severe diseases of liver, pancreatitis, and also heart failure.
  • Due to the high content of different synthetical medical elements in Tretinoin (Retin-A) this drug is strictly contraindicated to be used during pregnancy, in the period of lactation, and also by patients younger than 12 years old and older than 50 years old.

Possible Side effects

The patient may experience the side effects of the local character at the first week of Tretinoin (Retin-A) usage such as itching, feeling of burning, dryness of the skin, and irritation in the places of the cream application. Slight edema may also appear but all these side effects pass without medical intervention during the regular use of the drug.
In case of the severer side effects it is needed to see a doctor. 

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International name - tretinoin

Tretinoin (Retin - A) 20g/0.05%

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