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Lotrisone cream is a combined drug for the external use. It contains two active components – Clotrimazole and Betamethasone. This drug is used for the treatment of the different skin diseases which are caused by the fungal infections.

It is one of the most effective remedies for the treatment of the skin diseases. The pharmacological efficiency is explained by the action of two active components which supplement the pharmacological properties of each other.

Clotrimazole is an antifungal remedy with broad-spectrum action. It is active as to dermatophytes and yeast-like fungi. Moreover, it is active as to trichomonad, staphylococci, and streptococci. Its mechanism of the action consists in the penetration to DNA of the fungi cell and destruction of their intracellular compounds. Blocking the development and the growth of fungi on the molecular level this drug quickly reduces the disease symptoms and prevents the relapses.

Betamethasone is glucocorticosteroid, provides the anti-inflammatory, antipruritic and anti-allergic action. It influences on all phases of the inflammation. The anti-allergic action develops as a result of the reduction of the synthesis and secretion of the allergy mediators.

The medical interaction of Clotrimazole and Betamethasone allows to increase the efficiency of the treatment of the skin diseases both inflectional and allergic character. Lotrisone Cream is one of the most used remedies for the treatment of the skin diseases which differ by a good tolerance and absence of the severe side effects.

Direction for the use:

  • Athlete's foot
  • Jock itch
  • Dermatophytosis
  • Candidosis (including in the inguinal area)
  • Eczema
  • Dermatosis
  • Simple and allergic dermatitis
  • Simple chronic lichen
  • Atopic dermatitis

Common Use

  • Lotrisone cream is applied with the thin layer to the entire affected part of the skin and surrounding tissue 2 times per day (in the morning and evening). The cream should be slightly rubbed.
  • To provide the efficiency of the treatment the drug should be used regularly without missing any day.
  • The application of the big amount of the cream does not lead to the better result but the patient may experience the appearance of the systemic side reactions during the penetration of high doses of the active components.
  • The length of the therapy depends on the size and localization of the affection and also reaction of the patient.
  • If there is no clinical improvement in 3-4 weeks, it may be a sign to specify the diagnosis and change the course of the treatment.


  • It is necessary to avoid eyes while using Lotrisone cream. If the cream reached the eyes, it is needed to rinse eyes right away.
  • It is not recommended to apply the cream to the skin during tuberculosis of the skin, chickenpox, syphilis, herpes, and also open wounds and burns.
  • In case of the increased sensitivity to Clotrimazole or Betamethasone it is not necessary to start the treatment because the allergic reaction may appear.
  • It is necessary to use the drug during pregnancy with caution. A regular supervision of the doctor and having laboratory analyses are needed. If the allowed concentration of Clotrimazole or Betamethasone in the body of the pregnant woman is exceeded, it is needed to terminate the treatment.
  • Using Lotrisone cream it is needed to terminate the breast-feeding.

Possible Side effects

In case of the resistant bacterial or fungal microflora it is necessary to cancel the drug and prescribe the attendant therapy.

The most common local side reaction during the use of Lotrisone cream are itching, burning, irritation, dry skin, folliculitis, and high sweating.

Most side effects are temporary and pass in several days after the beginning of the treatment.

Using high doses of the cream to big parts of the skin the development of such side effects as increased arterial pressure, edemas, disorder of the organs of the gastrointestinal tract, and allergic reactions are possible. If these symptoms appear, the intervention of the medical doctor is needed.


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